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Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia
H Fukuda1, T Tomimatsu, N Watanabe
1Department of Obstetrics and Gynecology, Osaka University School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan. fukuda@gyne.med.osaka-u.ac.jp
Brain Research
|August 8, 2001
Abstract:
The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of caspase-3 activation may be an interventional point underlying the neuroprotective effect of hypothermia in neonates.