Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Substance P and spinal neurones.

J L Henry, K Krnjevíc, M E Morris

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Substance P (sP) strongly excites spinal cord neurons but acts slowly and is unlikely to be a fast-acting neurotransmitter. Its effects on cerebral cortical neurons are less pronounced.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography.

    Osteoarthritis and cartilage·2007
    Same author

    Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation.

    Neuroscience·2007
    Same author

    Development of the psychological impact of tinnitus interview: a clinician-administered measure of tinnitus-related distress.

    The international tinnitus journal·2004
    Same author

    Genistein directly blocks glycine receptors of rat neurons freshly isolated from the ventral tegmental area.

    Neuropharmacology·2003
    Same author

    Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons.

    Neuropharmacology·2002
    Same author

    Moderate hypoglycemia aggravates effects of hypoxia in hippocampal slices from diabetic rats.

    Neuroscience·2002

    Area of Science:

    • Neuroscience
    • Neuropharmacology

    Background:

    • Substance P (sP) is a neuropeptide implicated in pain transmission and other central nervous system functions.
    • Understanding the precise role of sP in neuronal signaling is crucial for developing targeted therapies.

    Purpose of the Study:

    • To investigate the excitatory and depressant effects of microiontophoretically applied substance P on mammalian neurons.
    • To determine the potential role of sP as a fast-acting synaptic transmitter in the central nervous system.

    Main Methods:

    • Microiontophoresis was used to apply substance P to neurons in the lumbar spinal cord and cerebral cortex of cats and rats.
    • Neuronal responses, including excitatory and depressant actions, were recorded and analyzed.
    • Effects on motoneuronal antidromic field potentials were also assessed.

    Related Experiment Videos

    Main Results:

    • Substance P exhibited a strong, slow, and prolonged excitatory action on approximately half of the tested lumbar spinal cord neurons.
    • Cerebral cortical neurons in cats and rats were less sensitive to sP compared to spinal interneurons.
    • Some neurons unresponsive to excitation showed evidence of a depressant effect by substance P.
    • Significant effects of sP on motoneuronal antidromic field potentials were infrequent.

    Conclusions:

    • Substance P demonstrates significant excitatory effects on spinal neurons, suggesting a role in central afferent pathways.
    • The slow and prolonged nature of sP's action indicates it is unlikely to function as a rapid synaptic transmitter.
    • Further research is needed to fully elucidate the complex roles of substance P in the central nervous system.