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Related Experiment Videos

Sweet's syndrome associated with encephalitis.

K Noda1, Y Okuma, J Fukae

  • 1Department of Neurology, Juntendo Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka, Tagata-gun, 410-2295, Shizuoka, Japan.

Journal of the Neurological Sciences
|August 8, 2001
PubMed
Summary
This summary is machine-generated.

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Central nervous system (CNS) involvement in Sweet's syndrome is rare. This case highlights acute encephalitis as a potential neurological complication, successfully treated with corticosteroids.

Area of Science:

  • Neurology
  • Dermatology
  • Infectious Diseases

Background:

  • Sweet's syndrome, or acute febrile neutrophilic dermatosis, is characterized by fever, neutrophilia, and tender dermal plaques.
  • Central nervous system (CNS) involvement is an uncommon manifestation of Sweet's syndrome.

Observation:

  • A 47-year-old woman presented with acute encephalitis, including altered consciousness, fever, and skin lesions.
  • Cerebrospinal fluid (CSF) analysis revealed neutrophilic pleocytosis without hypoglycemia.
  • Brain MRI demonstrated signal abnormalities in the basal ganglia and hippocampus.

Findings:

  • Skin biopsy confirmed dense dermal neutrophil infiltration, consistent with Sweet's syndrome.
  • Initial treatments with acyclovir and antibiotics were ineffective.

Related Experiment Videos

  • Corticosteroid therapy led to significant clinical improvement.

    • Implications:

    • Recognizing neurological complications in Sweet's syndrome is crucial for accurate diagnosis.
    • Prompt identification can prevent unnecessary treatments for presumed meningoencephalitis.
    • Corticosteroids represent an effective therapeutic option for CNS manifestations of Sweet's syndrome.