Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory inhibitory apraxia.

E A Atack, L Suranyi

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified a new condition, respiratory inhibitory apraxia (R.I.A.), where patients cannot voluntarily stop breathing. This inability is linked to specific brain lesions, suggesting a novel neurological disorder affecting respiratory control.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Localization of the "sneeze center".

    Neurology·2001
    Same author

    Loss of ability to sneeze in lateral medullary syndrome.

    Neurology·2000
    Same author

    Dissociation of spinothalamic sensation in lateral medullary infarction.

    Neurology·1998
    Same author

    Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs.

    American journal of medical genetics·1992
    Same author

    Prognosis in epilepsy and related disorders.

    Transactions of the Association of Life Insurance Medical Directors of America·1987
    Same author

    Hexosaminidase-A deficiency presenting as atypical juvenile-onset spinal muscular atrophy.

    Archives of neurology·1985

    Area of Science:

    • Neurology
    • Respiratory Medicine
    • Neuroscience

    Background:

    • Voluntary control over respiration is crucial for various functions.
    • Involuntary breathing mechanisms are distinct from voluntary respiratory control.
    • Previous literature lacks a defined condition for the inability to voluntarily inhibit breathing.

    Purpose of the Study:

    • To describe a newly identified neurological disorder: respiratory inhibitory apraxia (R.I.A.).
    • To investigate the clinical characteristics and potential underlying pathophysiology of R.I.A.
    • To explore associations between R.I.A. and other neurological deficits.

    Main Methods:

    • Clinical observation and description of ten patients presenting with inability to stop breathing on command.
    • Review of respiratory system anatomy and voluntary control mechanisms.

    Related Experiment Videos

  • Neurological examination and assessment for associated motor or inhibitory deficits.
  • Detailed neuropathological examination of one autopsied case.

    • Main Results:

    • Ten patients exhibited a consistent inability to voluntarily cease respiration, while spontaneous and stimulated breathing remained unaffected.
    • Respiratory inhibitory apraxia (R.I.A.) was observed to co-occur with other forms of apraxia and motor impersistence in some patients.
    • Urinary and bowel incontinence were noted in some cases, potentially representing a related inhibitory apraxia.
    • The autopsied case revealed a deep-seated lesion in the internal capsule affecting descending motor pathways, disconnecting the cortical respiratory inhibitory center.

    Conclusions:

    • Respiratory inhibitory apraxia (R.I.A.) is a distinct neurological condition characterized by the inability to voluntarily inhibit breathing.
    • R.I.A. is likely associated with lesions in the minor (typically left) cerebral hemisphere, often affecting deep structures.
    • The findings suggest that R.I.A. results from a disconnection between voluntary respiratory control centers and the descending motor pathways.