[Pathogenetic mechanisms of impaired intestinal microflora in patients with destructive pulmonary tuberculosis]

Following 2-3 months of combined chemotherapy, most (97.5%) patients with destructive pulmonary tuberculosis were found to develop pathological changes in the intestinal microflora. Of them 92.3% had bifidobacterium deficiency, which creates conditions for opportunistic microorganisms to colonize the bowel, promoting the development of an inflammatory process in the gastroduodenal area, Bifidobacterium deficiency being a pathogenetic factor and opportunistic microbes acting as an etiological factor of the impaired intestinal microflora. Assessing of dysbiotic impairments makes it possible to specify the mechanisms of development of toxic reactions and inflammatory processes in the digestive tract.