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Related Experiment Videos

Soluble adhesion molecules in inflammatory bowel disease.

M G Goggins1, J Goh, M A O'Connell

  • 1Departments of Clinical Medicine and Gastroenterology, Trinity College and St James's Hospital, Dublin, Ireland.

Irish Journal of Medical Science
|August 9, 2001
PubMed
Summary

Soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin are elevated in inflammatory bowel disease (IBD). However, C-reactive protein (CRP) and microalbuminuria are more accurate markers of disease activity.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Biomarker Discovery

Background:

  • Soluble adhesion molecules are commonly elevated in various inflammatory conditions.
  • Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract.

Purpose of the Study:

  • To evaluate the association between soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels and the activity of inflammatory bowel disease (IBD).

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify sICAM-1 and sE-selectin levels.
  • The study included 53 patients with ulcerative colitis (UC) and 38 patients with Crohn's disease (CD).

Main Results:

  • Elevated sICAM-1 levels were observed in patients with active UC and CD compared to inactive disease and controls.

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  • Patients with pancolitis showed significantly higher sICAM-1 levels than those with distal colitis.
  • While sE-selectin levels differed between active CD patients and controls, neither sICAM-1 nor sE-selectin correlated with the Harvey Bradshaw Index (HBI); CRP and microalbuminuria showed better correlation with disease activity and serum tumor necrosis factor-alpha (TNF-alpha).

    • Conclusions:

    • Soluble adhesion molecules sICAM-1 and sE-selectin are elevated in IBD patients' serum.
    • C-reactive protein (CRP) and microalbuminuria are more precise indicators of clinical disease activity in IBD.
    • The routine use of soluble adhesion molecules as disease activity markers in IBD is not supported by this study.