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The role of apoptotic cell death in cardiovascular disease
R McLaughlin1, C J Kelly, E Kay
1Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Insights
Programmed cell death, or apoptosis, is a critical process in cardiovascular disease. Understanding apoptosis offers new therapeutic strategies for conditions like heart failure and myocardial infarction.
Area of Science:
- Cardiovascular Science
- Cell Biology
- Pathophysiology
Background:
- Apoptosis, a regulated, energy-dependent cell death, differs significantly from necrosis.
- It plays a crucial role in cardiovascular disease pathogenesis.
- This review explores apoptosis's initiation, propagation, and significance in the cardiovascular system.
Purpose of the Study:
- To review the current understanding of apoptosis in cardiovascular disease.
- To assess the therapeutic potentials related to apoptosis in cardiovascular conditions.
Main Methods:
- A comprehensive Medline search was conducted.
- Relevant publications were reviewed and supplemented with reference-derived articles.
Main Results:
- Apoptotic cell death is integral to ischaemia-reperfusion injury, cardiac failure, myocardial infarction, atherosclerosis, and endothelial dysfunction.
- These processes contribute to various clinical cardiovascular syndromes.
Conclusions:
- Increased knowledge of apoptosis's role in cardiovascular disease pathogenesis opens avenues for novel therapeutic strategies.
- Targeting apoptosis may provide new treatment options for cardiovascular conditions.
Background:
Programmed cell death, or apoptosis, is a distinct, managed form of cell death. It is fundamentally different from necrosis. It is a genetically controlled, energy-dependent method of cellular deletion without inflammation. In the cardiovascular system, apoptosis occurs as a primary and secondary event in disease pathogenesis. This review addresses our current understanding of the initiation, propagation and significance of apoptosis in the cardiovascular system, as well as assessing therapeutic potentials arising therefrom.
Methods:
A Medline search was performed and relevant publications reviewed. Further articles were obtained from the references of these publications.
Results:
and conclusions Apoptotic cell death is a key element in the pathogenesis and progression of ischaemia-reperfusion (IR) injury, cardiac failure, myocardial infarction, atherosclerosis, endothelial dysfunction and the clinical syndromes which these situations produce. Our increased understanding of the role of apoptosis in the pathogenesis of cardiovascular disease offers potential to develop new therapeutic strategies.