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Related Experiment Videos

Antacid-induced rickets in infancy.

A Pattaragarn1, U S Alon

  • 1Section of Pediatric Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, USA.

Clinical Pediatrics
|August 9, 2001
PubMed
Summary
This summary is machine-generated.

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Pediatrics·2001

A premature infant developed rickets from high-dose antacids. Prompt treatment with phosphate and vitamin D resolved the condition, highlighting the risks of aluminum-based antacids in infants.

Area of Science:

  • Pediatrics
  • Biochemistry
  • Pediatric Endocrinology

Background:

  • Rickets is a condition causing bone softening in children.
  • Premature infants are at higher risk for nutritional deficiencies and metabolic bone disease.

Observation:

  • A 3-month-old premature infant presented with a soft skull, diagnosed as rickets.
  • The infant had received high-dose aluminum-rich antacids for 5-6 weeks.
  • Biochemical tests showed normal parathyroid hormone (PTH) and undetectable urine phosphate.

Findings:

  • The clinical, radiologic, and biochemical presentation confirmed antacid-induced rickets.
  • Normal serum PTH and hypophosphaturia are key indicators in infants.
  • Hypocalciuria was observed, differing from hypercalciuria seen in adults.

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Implications:

  • Aluminum-containing antacids can rapidly induce rickets in premature infants.
  • Pediatricians should limit the use of these antacids and monitor mineral metabolism.
  • Early diagnosis and treatment with phosphate and vitamin D lead to rapid recovery.