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Updated: Aug 11, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
Published on: August 6, 2015
Evidence for stunned myocardium in humans: a 2001 update
R A Kloner1, R B Arimie, G L Kay
1Heart Institute, Good Samaritan Hospital, Los Angeles, California 90017, USA. rkloner@goodsam.org
This review updates clinical understanding of myocardial stunning, a heart muscle dysfunction. It covers causes like angioplasty and surgery, and newer concepts such as neurogenic stunned myocardium.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Myocardial stunning is a transient left ventricular dysfunction that occurs after brief periods of ischemia.
- It is a well-recognized phenomenon following reperfusion therapy for acute myocardial infarction.
Purpose of the Study:
- To describe clinical situations where myocardial stunning occurs.
- To update previous reviews on the topic of myocardial stunning.
- To discuss newer concepts and clinical implications of myocardial stunning.
Main Methods:
- Review of existing literature on myocardial stunning.
- Inclusion of clinical scenarios and case examples.
- Discussion of recent advancements and emerging concepts in myocardial stunning.
Main Results:
- Stunning is observed following angioplasty, angina, exercise-induced ischemia, infarction, and cardiac surgery.
- Neurogenic stunned myocardium is a newly discussed concept.
- Left atrial stunning after cardioversion is a distinct, recently recognized phenomenon.
Conclusions:
- Myocardial stunning is a complex phenomenon with diverse clinical presentations.
- Understanding the various causes and types of stunning is crucial for patient management.
- Further research is needed to fully elucidate the mechanisms and implications of neurogenic and left atrial stunning.
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