Related Experiment Video
Updated: Jul 31, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Comparison of the resorbable barrier interceed (TC7) and preoperative use of medroxyprogesterone acetate in
1University of Istanbul, Istanbul Medical School Hospital, Capa, Turkey.
Purpose:
The purpose of this study was to compare the effectiveness of barrier agent Interceed (TC7) (Johnson & Johnson Medical, Inc) and preoperative use of commonly used progesterone, medroxyprogesterone acetate.
Methods:
Forty-five Spraque-Dawley white rats of reproductive age (225-250 g) were employed as a model for postsurgical adhesion formation. Group 1 consisted of control rats, Group 2 consisted only of rats with Interceed applied to the denuded areas, Group 3 consisted of rats where preoperative MPA was used. Fifteen rats were exposed to daily IM injections of 15 mg medroxyprogesterone acetate (MPA) two weeks before the surgery.
Results:
The total adhesion score of the MPA group was significantly less than the control and Interceed group respectively (chi2=10.15) (p<0.001), (chi2=4.67) (p<0.03). There was no significant difference between the Interceed and the control group (p>0.05).
Conclusion:
Preoperative long-term MPA treatment significantly decreases primary adhesion formation. It seems that there are some other mechanisms responsible for this effect rather than anti-inflammation and/or immunosuppression. It may be that the hypoestrogenic milieu depends on the use of progesterone.
