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Eclalbatin, a triterpene saponin from Eclipta alba.

R K Upadhyay1, M B Pandey, R N Jha

  • 1Department of Medicinal Chemistry, Banaras Hindu University, Varanasi, India.

Journal of Asian Natural Products Research
|August 9, 2001
PubMed
Summary

Researchers isolated a new triterpene saponin, eclalbatin, from Eclipta alba. Its structure was determined using chemical and spectral analysis, revealing a novel compound with potential therapeutic applications.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Eclipta alba (L.) Hassk. is a medicinal plant with a history of traditional use.
  • Triterpene saponins are a class of natural compounds known for diverse biological activities.
  • Previous research has identified various compounds from Eclipta alba, but novel saponins remain of interest.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from the whole plant of Eclipta alba.
  • To elucidate the chemical structure of a newly discovered triterpene saponin.

Main Methods:

  • Extraction of compounds from the whole plant of Eclipta alba.
  • Isolation of constituents using chromatographic techniques.
  • Structure elucidation of the new compound (eclalbatin) via comprehensive chemical and spectral analyses (e.g., NMR, Mass Spectrometry).

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Main Results:

  • Isolation of eclalbatin, a novel triterpene saponin.
  • Co-isolation of known compounds: alpha-amyrin, ursolic acid, and oleanolic acid.
  • The structure of eclalbatin was determined as 3-O-beta-D-glucopyranosyl-3-beta-hydroxy-olean-12-en-28-oic acid, 28-O-beta-D-arabinopyranoside.

Conclusions:

  • A new triterpene saponin, eclalbatin, has been successfully isolated and structurally characterized from Eclipta alba.
  • The findings contribute to the phytochemical knowledge of Eclipta alba and provide a basis for further investigation into the biological activities of eclalbatin.