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Related Experiment Videos

Reduced baroreflex sensitivity with volume loading in conscious dogs.

S F Vatner, D H Boettcher, G R Heyndrickx

    Circulation Research
    |August 1, 1975
    PubMed
    Summary

    The Bainbridge reflex shows that increased blood volume raises heart rate. This response is mediated by atrial receptors, not arterial baroreceptors, and is reduced by higher atrial pressures.

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    Area of Science:

    • Cardiovascular Physiology
    • Autonomic Nervous System Regulation

    Background:

    • The Bainbridge reflex describes the heart rate increase following intravenous fluid administration.
    • The precise mechanisms and baroreceptor involvement in this reflex remain incompletely understood.

    Purpose of the Study:

    • To investigate the role of arterial baroreceptors in the Bainbridge reflex.
    • To elucidate the influence of atrial pressure on heart rate regulation during volume loading.

    Main Methods:

    • Studied the Bainbridge reflex in 12 conscious dogs undergoing rapid saline infusion.
    • Utilized beta-receptor blockade, cholinergic blockade, and vagotomy to assess neural influences.
    • Assessed arterial baroreceptor reflex sensitivity using the pulse interval/systolic arterial pressure slope after methoxamine administration.

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    Main Results:

    • Saline infusion increased mean arterial pressure, atrial pressure, and heart rate.
    • Heart rate response was attenuated by beta-receptor blockade and blocked by cholinergic or combined blockade after vagotomy.
    • Arterial baroreceptor denervation did not alter the heart rate response to volume loading.
    • Increased atrial pressure progressively reduced arterial baroreflex sensitivity.

    Conclusions:

    • The Bainbridge reflex is primarily mediated by atrial receptors, not arterial baroreceptors.
    • Elevated atrial pressure diminishes arterial baroreflex sensitivity, allowing heart rate to increase despite rising arterial pressure.