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Related Experiment Videos

ret/PTC-1 Activation in Hashimoto Thyroiditis.

O. M. Sheils1, J.J. O'eary, V. Uhlmann

  • 1Department of Histopathology, Trinity College, Dublin, Ireland.

International Journal of Surgical Pathology
|August 9, 2001
PubMed
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The ret/PTC-1 (rearranged during transfection/papillary thyroid carcinoma) transcript was found in 78% of nonlymphomatous thyroid lymphoid infiltrates. This suggests ret/PTC-1 may indicate thyroid cell activation or early malignant transformation.

Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • The ret/PTC-1 oncogene is detected in a small percentage of papillary thyroid carcinomas (PTC).
  • Previous research identified ret/PTC-1 in 58% of PTC cases with lymphocytic thyroiditis (LT).

Purpose of the Study:

  • To investigate the incidence of ret/PTC-1 expression in various nonlymphomatous thyroid lymphoid infiltrates.
  • To explore the potential role of ret/PTC-1 in thyroid disease pathogenesis.

Main Methods:

  • TaqMan RT-PCR was used to analyze 27 thyroid tissue samples with nonlymphomatous lymphoid infiltration.
  • Samples included Hashimoto thyroiditis and other forms of lymphocytic thyroiditis.

Main Results:

  • The ret/PTC-1 transcript was detected in 78% (21/27) of the analyzed cases.

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  • Eighteen of 18 Hashimoto thyroiditis cases (100%) were positive for ret/PTC-1.
  • Three of 7 lymphocytic thyroiditis cases (43%) showed ret/PTC-1 activation.

    • Conclusions:

    • Ret/PTC-1 activation may serve as an indicator of follicular thyroid cell activation.
    • Alternatively, ret/PTC-1 activation could be an early event in thyroid cancer development.
    • This activation might trigger an autoimmune response, potentially influencing PTC progression and thyroid destruction.