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Platelet sodium-hydrogen exchanger activity and left ventricular mass
T K Khong1, G A Sagnella, N D Markandu
1Blood Pressure Unit, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. tkhong@sghms.ac.uk
Journal of Human Hypertension
|August 9, 2001
Summary
Platelet sodium-hydrogen exchanger (NHE) activity showed no significant correlation with left ventricular mass index (LVMI). These findings suggest that the relationship between LVMI and NHE activity may be cell-type specific.
Area of Science:
- Cardiology
- Biochemistry
- Cell Physiology
Background:
- The sodium-hydrogen exchanger (NHE) plays a role in cell growth and may contribute to left ventricular hypertrophy (LVH).
- Investigating NHE activity in accessible cells like platelets could offer insights into LVH development.
Purpose of the Study:
- To determine the relationship between platelet sodium-hydrogen exchanger (NHE) activity and left ventricular mass index (LVMI).
Main Methods:
- Assessed platelet NHE activity by measuring the rate of sodium-dependent intracellular pH recovery in 20 untreated Caucasian males.
- Calculated LVMI using M-mode echocardiography.
- Analyzed correlations between platelet NHE activity, LVMI, and blood pressure using parametric tests.
Main Results:
- Platelet NHE activity was not significantly correlated with LVMI (r = 0.06; P = 0.8).
- No significant correlation was found between LVMI and systolic or diastolic blood pressure.
- Platelet NHE activity did not differ between subjects with and without left ventricular hypertrophy.
Conclusions:
- Platelet NHE activity is not significantly correlated with LVMI in this cohort.
- The association between LVMI and NHE activity may be cell-type dependent, differing from findings in leukocytes and erythrocytes.
