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Updated: Jul 25, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Sequential transplantation induces islet allograft tolerance.

J Sun¹, X Wang, C Wang

¹Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, University of Sydney, Sydney, N.S.W. 2006, Australia. jhsun@mail.usyd.edu.au

|August 9, 2001

Summary

Liver transplantation (LT) can induce tolerance to islet allografts. Sequential LT before or after islet transplantation (IT) led to indefinite islet graft survival, unlike concurrent procedures.

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Area of Science:

Immunology
Transplantation Biology
Endocrinology

Background:

Liver transplantation (LT) can induce donor-specific tolerance to other organ grafts in certain rat models.
The impact of LT on the fate of islet allografts, crucial for treating type 1 diabetes, remains incompletely understood.

Purpose of the Study:

To investigate the effect of liver transplantation on the survival and acceptance of islet allografts.
To determine if LT can prevent or reverse rejection of concurrently or sequentially transplanted islet allografts.

Main Methods:

Islet isolation via collagenase digestion and dextran-gradient purification.
Orthotopic liver transplantation and subcapsular islet transplantation in streptozotocin-induced diabetic rats.
Evaluation of islet allograft survival and host immune response.

Main Results:

Concurrent LT and islet transplantation (IT) resulted in modest prolongation of islet allograft survival.
Sequential LT (before or after IT) led to indefinite survival of islet allografts.
LT demonstrated the ability to delay or reverse ongoing islet graft rejection.
IT could precipitate rejection of previously tolerated liver grafts.

Conclusions:

Sequential liver and islet transplantation strategies can induce specific tolerance to islet allografts.
The timing of LT relative to IT influences the outcome, suggesting distinct immunological mechanisms.
Islet transplantation can potentially trigger rejection of established liver grafts, highlighting complex immune interactions.