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[Hepatitis C in hemodialysis patients]
M Miyano1, H Tanaka, S Ishitani
1Nishide Hospital.
Insights
Hepatitis C Virus (HCV) RNA was detected in 61.1% of anti-HCV-positive and 16.0% of anti-HCV-negative hemodialysis patients. Higher viral loads were observed in anti-HCV-positive individuals.
Area of Science:
- Hepatology
- Virology
- Nephrology
Context:
- Chronic hepatitis C (HCV) is a significant concern in patients undergoing hemodialysis.
- Assessing HCV infection markers and viral load is crucial for managing these vulnerable patients.
Purpose:
- To investigate the characteristics of chronic hepatitis C infection in hemodialysis patients.
- To compare HCV RNA positivity and viral load based on anti-HCV antibody status.
Summary:
- Out of 99 hemodialysis patients, 18 were anti-HCV-positive and 81 were anti-HCV-negative.
- HCV RNA was detected in 61.1% of anti-HCV-positive and 16.0% of anti-HCV-negative patients.
- Significantly higher HCV RNA levels (>100 K copies/ml) were found in the anti-HCV-positive group, indicating a more active infection. Histological findings often did not correlate with clinical presentation.
Impact:
- This study highlights the importance of HCV RNA testing in hemodialysis patients, even those negative for anti-HCV antibodies.
- Understanding viral load differences based on serological status can inform treatment strategies.
- The discrepancy between histological diagnosis and clinical features underscores the complexity of managing chronic hepatitis C in this population.
Abstract:
Characteristics of chronic hepatitis C in 99 hemodialysis patients were studied. Eleven out of 18 anti-HCV-positive patients(61.1%) and 13 out of 81 anti-HCV-negative patients (16.0%) were HCV-RNA-positive. Twenty four HCV-RNA-positive patients were divided into 2 groups according to anti-HCV-positivity. Seven out of 11 patients in anti-HCV-positive group and 1 out of 13 in anti-HCV-negative group were infected with more than 100 K copies/ml of HCV. A number of HCV-RNA copy was significantly larger in anti-HCV-positive group. Fourteen biopsies and necropsies in hemodialysis were achieved and the histological diagnosis did not correspond to clinical feature of chronic hepatitis C.