Related Experiment Video
Updated: Aug 6, 2026

A Hydrophobic Tissue Clearing Method for Rat Brain Tissue
Published on: December 23, 2020
Rantes distribution and cellular localization in the brain of HIV-infected patients
L Vago1, M Nebuloni, S Bonetto
1Pathology Unit, L. Sacco Institute of Medical Science, University of Milan, Milano, Italy.
Objective:
To study the immunochemical distribution ofRantes chemokine and its correlation with HIV-p24 expression, in brains with HIV-related lesions.
Material And Methods:
17 HIV-positive cases of HIV-related brain lesions, 7 HIV-positive cases without cerebral HIV-related lesions (5 with opportunistic brain diseases), and 7 HIV-negative cases as controls (4 with brain lesion) were selected.
Results:
High expression of Rantes was observed in the cases with inflammatory brain lesions (22/24 HIV-positive and 2/7 HIV-negative patients). Positivity was observed in the diffuse and nodular microglial cells and lymphocytes. In the patients with HIV-related lesions, the presence of Rantes-stained microglia did not correlate with that of HIV-p24-positive cells. Positive astrocytes were only found in the HIV-positive patients. Multinucleated giant cells were always Rantes-negative.
Conclusions:
Our results seem to demonstrate the role of Rantes chemokine in inducing inflammatory brain perivascular and microglial reactions both in HIV-positive and -negative patients.
Related Concept Videos
Retrovirus Life Cycles
Rabies
Respiratory Syncytial Virus Disease
Cryptococcal Meningitis
Encephalitis ll: Pathophysiology

