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Updated: Jul 26, 2026

Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
Published on: January 1, 2018
Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms)
T A Grese1, M D Adrian, D L Phillips
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. grese@lilly.com
Abstract:
Selective estrogen receptor modulators are an emerging class of pharmaceutically important molecules. Many compounds in this class contain an aminoethoxyaryl moiety attached to a polycyclic framework at an asymmetric carbon atom. To assess whether this carbon atom can be replaced by nitrogen, we have employed a Ninomiya enamide photocyclization for the rapid synthesis of a novel N-arylbenzophenanthridine framework, 4. Further elaboration of 4 into a new structural class of achiral, nonsteroidal estrogen receptor modulators is described.
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