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Related Experiment Video

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Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

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Published on: April 1, 2014

Risk factors for meningococcal disease in college students.

M G Bruce¹, N E Rosenstein, J M Capparella

¹Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop C-09, Atlanta, GA 30333, USA.

|August 10, 2001

Summary

College students, especially freshmen in dorms, face higher risks of meningococcal disease. Vaccination can significantly reduce this risk.

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Area of Science:

Epidemiology
Infectious Diseases
Public Health

Background:

Meningococcal disease rates were notably high in 18- to 22-year-olds in the mid-1990s.
National data collection for US college students began in 1998.

Purpose of the Study:

To determine meningococcal disease rates in US college students.
To identify risk factors for meningococcal disease in this demographic.

Main Methods:

A prospective surveillance and nested case-control study was conducted.
Data were collected from US college students between September 1998 and August 1999.
Fifty state health departments and 231 college health centers participated.

Main Results:

Ninety-six cases of meningococcal disease were identified among US college students.
Undergraduates had a lower incidence rate (0.7/100,000) than the general 18- to 23-year-old non-student population (1.4/100,000).
Freshmen residing in dormitories exhibited the highest incidence rate (5.1/100,000) and an elevated risk (OR, 3.6).
A majority of cases (68%) were caused by vaccine-preventable serogroups.

Conclusions:

Freshmen living in dormitories have an independent, elevated risk of meningococcal disease.
The quadrivalent polysaccharide vaccine could substantially decrease meningococcal disease risk in college students.