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Published on: July 19, 2017
Vasopressin into the preoptic area increases grooming behavior in mice
L A Lumley1, C L Robison, W K Chen
1Division of Neuroscience, Department of Neurochemistry and Neuroendocrinology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, 20910-7500, Silver Spring, MD, USA. lucille.lumley@na.amedd.army.mil
Physiology & Behavior
|August 10, 2001
Summary
Arginine-8-vasopressin (AVP) in mice
Area of Science:
- Neuroscience
- Behavioral Science
Background:
- Arginine-8-vasopressin (AVP) is a neuropeptide known to influence behavior.
- Previous studies show AVP induces grooming and hyperactivity in mice and flank marking in hamsters.
Purpose of the Study:
- To investigate the specific behavioral effects of AVP administration into the preoptic area (POA) of male C57BL/6 mice.
Main Methods:
- AVP was administered intracerebroventricularly into the POA of male C57BL/6 mice at doses of 0, 1, and 10 ng/250 nl.
- Behavioral responses, including grooming, scratching, rearing, and olfactory investigation, were measured.
Main Results:
- AVP administration into the POA significantly increased hindleg scratching and face washing.
- Rearing and olfactory investigation behaviors were inhibited by AVP in the POA.
Conclusions:
- The preoptic area (POA) is identified as a key brain region where AVP modulates grooming behaviors in mice.
- These findings contribute to understanding the neurobiological mechanisms underlying AVP-induced behaviors.
