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Related Experiment Videos

Interactions between rotavirus and gastrointestinal cells.

M Ciarlet1, M K Estes

  • 1Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Room 923E, Mailstop BCM-385, Houston, TX 77030, USA.

Current Opinion in Microbiology
|August 10, 2001
PubMed
Summary
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Rotaviruses cause severe diarrhea in infants and animals. Their disease mechanisms, involving toxins and gut nerve activation, resemble bacterial pathogens, suggesting shared pathways.

Area of Science:

  • Virology and Gastroenterology
  • Microbial Pathogenesis

Background:

  • Rotaviruses are a primary cause of severe diarrheal illness globally in young children and animals.
  • The cellular responses to rotavirus infection are more intricate than previously understood.

Purpose of the Study:

  • To explore the complex cellular responses induced by rotavirus infection.
  • To investigate potential shared pathogenic mechanisms between rotaviruses and bacterial pathogens.

Main Methods:

  • Analysis of cellular responses in intestinal epithelial cells following rotavirus infection.
  • Comparative analysis of rotavirus and bacterial pathogenesis pathways.

Main Results:

  • Rotavirus infection triggers diverse cellular responses beyond initial assumptions.

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  • Pathogenesis involves an enterotoxin, enteric nervous system activation, and malabsorption.
  • These mechanisms show parallels with those observed in bacterial infections.

    • Conclusions:

    • Rotavirus pathogenesis is complex, involving multiple cellular and systemic responses.
    • Common pathogenic mechanisms may exist between viral (rotavirus) and bacterial agents causing diarrheal disease.