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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Borna disease: virus-induced neurobehavioral disease pathogenesis
K M Carbone1, S A Rubin, Y Nishino
1FDA/CBER, Laboratory of Pediatric and Respiratory Viral Diseases, HFM 460, 8800 Rockville Pike, Bethesda, Maryland 20892, USA. Carbonek@cber.fda.gov
Current Opinion in Microbiology
|August 10, 2001
Summary
Borna disease virus (BDV) infection in rats shows an endogenous brain inflammatory response, impacting neurotransmitters like serotonin and norepinephrine. Research continues on BDV
Area of Science:
- Neurovirology
- Neuroimmunology
- Pathogenesis of viral diseases
Background:
- Borna disease virus (BDV) is increasingly studied for its role in neurobehavioral diseases.
- Recent findings include vertical transmission in horses and isolation of a novel BDV variant (No/98).
Purpose of the Study:
- To investigate the pathogenesis of neurobehavioral diseases linked to Borna disease virus infections.
- To explore the inflammatory and neurochemical changes in the brain following neonatal BDV infection in a rat model.
Main Methods:
- Neonatal infection of rats with Borna disease virus.
- Analysis of brain tissue for inflammatory markers, including cytokine and chemokine mRNA expression.
- Measurement of neurotransmitter levels, such as serotonin and norepinephrine.
Main Results:
- Neonatally BDV-infected rats lacking blood-borne brain inflammation exhibited significant endogenous brain inflammatory responses.
- Elevated expression of cytokine and chemokine mRNA was observed in the infected rat brains.
- Abnormal levels of neurotransmitters, including serotonin and norepinephrine, were associated with BDV infection.
Conclusions:
- Borna disease virus infection in rats triggers an endogenous inflammatory response within the brain.
- The infection leads to significant alterations in neurotransmitter systems.
- Further research is needed to clarify the role of Borna disease virus in human infections and psychiatric disorders.
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