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Renal effects of cyclooxygenase-2 selective inhibitors
1Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. cyharris@iupui.edu
Current Opinion in Nephrology and Hypertension
|August 10, 2001
Abstract:
Recent in-vitro and animal data show that cyclooxygenase-2 has an integral role in the physiology and pathophysiology of the kidney. Cyclooxygenase-2 regulates renin-angiotensin secretion, and thereby glomerular filtration rate and sodium homeostasis. It is also important for protecting against hypertonic stress. As a consequence, it is not surprising that clinical data verify that selective inhibitors of cyclooxygenase-2 affect renal function to a degree similar to that which has previously been documented with nonselective nonsteroidal anti-inflammatory drugs.