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No association between a promoter dopamine D(4) receptor gene variant and schizophrenia
E G Jönsson1, R Ivo, K Forslund
1Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE-171, 76 Stockholm, Sweden. erikj@psyk.ks.se
American Journal of Medical Genetics
|August 10, 2001
Abstract:
The dopamine D(4) receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D(4) receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant case control differences emerged. The present results do not support a major role for DRD4 in the etiology of schizophrenia among Caucasians from Sweden.