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[Hyperthyroidism, jaundice, and pulmonary hypertension].

G Mozo Herrera1, M J Fernández González, J Salgado Blanco

  • 1Servicio de Medicina Interna, Hospital Universitario, Valladolid.

Anales De Medicina Interna (Madrid, Spain : 1984)
|August 11, 2001
PubMed
Summary

Thyroid dysfunction can cause liver problems and pulmonary hypertension. Treating hyperthyroidism in a 66-year-old woman resolved these issues, suggesting a direct link between thyroid function and these conditions.

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Area of Science:

  • Endocrinology
  • Cardiology
  • Hepatology

Background:

  • Thyroid dysfunction, particularly hyperthyroidism, can manifest with various systemic complications.
  • Hepatic function test abnormalities and pulmonary arterial hypertension are recognized, though less common, manifestations of hyperthyroidism.

Observation:

  • A 66-year-old woman with toxic multinodular goiter hyperthyroidism presented with jaundice and severe pulmonary hypertension.
  • These conditions were unexplained by other causes and were not associated with autoimmune pathology.

Findings:

  • Thyroid function normalization led to the regression of both jaundice and pulmonary hypertension.
  • This case highlights the potential for direct impact of thyroid hormones on liver and pulmonary vasculature.

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Implications:

  • Suggests that hyperthyroidism itself, independent of heart failure, can cause significant hepatic and pulmonary dysfunction.
  • Underscores the importance of assessing thyroid function in patients with unexplained liver test abnormalities and pulmonary hypertension.
  • Treatment of hyperthyroidism may reverse these serious complications, offering a therapeutic target.