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Related Experiment Videos

Metabolic alterations in dogs with osteosarcoma.

E M Mazzaferro1, T B Hackett, T P Stein

  • 1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.

American Journal of Veterinary Research
|August 11, 2001
PubMed
Summary

Dogs with osteosarcoma (OSA) exhibit altered resting energy expenditure (REE) and metabolism, including decreased protein synthesis and increased glucose flux, even without cachexia.

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Area of Science:

  • Veterinary oncology
  • Canine metabolism
  • Nutritional biochemistry

Background:

  • Osteosarcoma (OSA) is a common bone cancer in dogs.
  • Metabolic changes associated with neoplasia are not well-characterized in canine patients.
  • Understanding these changes is crucial for managing patient health and treatment outcomes.

Purpose of the Study:

  • To investigate alterations in resting energy expenditure (REE) and protein and carbohydrate metabolism in dogs with OSA.
  • To compare metabolic parameters between dogs with OSA and healthy controls.

Main Methods:

  • Indirect calorimetry was used to measure REE and respiratory quotient (RQ).
  • Stable isotope tracers (15N-glycine and deuterium-glucose) assessed protein synthesis and glucose flux.

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  • Dual-energy x-ray absorptiometry (DEXA) determined body composition.

    • Main Results:

    • Dogs with OSA showed significantly higher REE compared to controls, both pre- and post-surgery.
    • Protein synthesis rates were decreased, and urinary nitrogen loss and glucose flux were increased in dogs with OSA, particularly postoperatively.
    • No significant differences in RQ were observed between groups.

    Conclusions:

    • Dogs with osteosarcoma exhibit significant metabolic derangements, including altered energy expenditure and substrate utilization.
    • These metabolic changes in canine OSA mirror those seen in human cancers.
    • The observed alterations in REE, protein, and carbohydrate metabolism occur even in the absence of clinical cachexia.