Related Experiment Videos
Metabolic alterations in dogs with osteosarcoma
E M Mazzaferro1, T B Hackett, T P Stein
1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
American Journal of Veterinary Research
|August 11, 2001
Summary
Dogs with osteosarcoma (OSA) exhibit altered resting energy expenditure (REE) and metabolism, including decreased protein synthesis and increased glucose flux, even without cachexia.
Area of Science:
- Veterinary oncology
- Canine metabolism
- Nutritional biochemistry
Background:
- Osteosarcoma (OSA) is a common bone cancer in dogs.
- Metabolic changes associated with neoplasia are not well-characterized in canine patients.
- Understanding these changes is crucial for managing patient health and treatment outcomes.
Purpose of the Study:
- To investigate alterations in resting energy expenditure (REE) and protein and carbohydrate metabolism in dogs with OSA.
- To compare metabolic parameters between dogs with OSA and healthy controls.
Main Methods:
- Indirect calorimetry was used to measure REE and respiratory quotient (RQ).
- Stable isotope tracers (15N-glycine and deuterium-glucose) assessed protein synthesis and glucose flux.
- Dual-energy x-ray absorptiometry (DEXA) determined body composition.
Main Results:
- Dogs with OSA showed significantly higher REE compared to controls, both pre- and post-surgery.
- Protein synthesis rates were decreased, and urinary nitrogen loss and glucose flux were increased in dogs with OSA, particularly postoperatively.
- No significant differences in RQ were observed between groups.
Conclusions:
- Dogs with osteosarcoma exhibit significant metabolic derangements, including altered energy expenditure and substrate utilization.
- These metabolic changes in canine OSA mirror those seen in human cancers.
- The observed alterations in REE, protein, and carbohydrate metabolism occur even in the absence of clinical cachexia.