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Active membrane fluctuations studied by micropipet aspiration.
J B Manneville1, P Bassereau, S Ramaswamy
1UMR CNRS-Curie 168, Institut Curie 26 Rue d'Ulm, 75248 Paris Cedex 05, France.
Summary
This study analyzes active membrane behavior in micropipet experiments. Our derived expressions accurately predict membrane tension and active noise effects, explaining experimental observations.
Area of Science:
- Biophysics
- Soft Matter Physics
- Membrane Biophysics
Background:
- Active membranes possess internal nonequilibrium noise sources.
- Micropipette aspiration experiments probe membrane mechanics.
Purpose of the Study:
- To analyze micropipet experiments on active membranes.
- To derive theoretical expressions for membrane tension and active noise effects.
- To explain experimental observations regarding active membrane behavior.
Main Methods:
- Detailed theoretical analysis of active membrane mechanics.
- Derivation of membrane tension as a function of areal strain.
- Incorporation of active centers' effects on membrane and fluid dynamics.
- Coupling of active center density with membrane curvature.
Main Results:
- Developed general expressions for active membrane behavior.
- Successfully reproduced experimental data from Manneville et al. (1999).
- Showed that active noise parameters explain observed effects and insensitivity to active-center density.
Conclusions:
- The theoretical framework accurately describes active membrane mechanics.
- Active noise is a key factor in observed membrane tension variations.
- The model provides a robust explanation for experimental findings in active membranes.