Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methylphenidate effects on avoidance learning at two ages in the rat.

E F Gauron, V N Rowley

    European Journal of Pharmacology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term follow-up of patients with chronic back pain treated in a multidisciplinary rehabilitation program.

    Spine·1995
    Same author

    The art of cognitive self-regulation.

    Clinics in sports medicine·1986
    Same author

    Critical periods for diphenylhydantoin and phenobarbital administration during gestation.

    Psychological reports·1980
    Same author

    A failure to replicate cross-generational effects of diphenylhydantoin in an F1 offspring group.

    Psychological reports·1978
    Same author

    Effects of chronic administration of diphenylhydantoin on learning and offspring behavior.

    Psychopharmacology·1977
    Same author

    Effects of methylphenidate on avoidance learning in the aged rat.

    The Journal of general psychology·1977

    Methylphenidate did not significantly alter avoidance learning in rats. However, higher doses and later administration improved performance, suggesting age-dependent effects of methylphenidate on learning.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Animal Behavior

    Background:

    • Methylphenidate is a stimulant medication.
    • Its effects on learning and development are of interest.
    • Investigating age-related responses to methylphenidate is crucial.

    Purpose of the Study:

    • To evaluate methylphenidate's impact on avoidance learning in rats.
    • To examine how age at drug initiation influences learning outcomes.
    • To determine dose-dependent effects of methylphenidate on avoidance behavior.

    Main Methods:

    • 96 naive albino rats (male and female) were used.
    • Rats received methylphenidate (0.5, 1.5, 4.5 mg/kg) or control daily for 18 days.
    • Avoidance conditioning trials were conducted after drug administration.

    Related Experiment Videos

    Main Results:

    • No significant difference in avoidance learning between methylphenidate and control groups.
    • A dose-dependent effect was observed: higher doses (4.5 mg/kg) showed more correct responses than lower doses (1.5 mg/kg).
    • Rats starting methylphenidate at 87 days old performed significantly better than those starting at 47 days old.

    Conclusions:

    • Methylphenidate administration did not broadly affect avoidance learning acquisition in this study.
    • Age of initiation significantly impacts methylphenidate's efficacy on avoidance learning.
    • Dose-dependent effects suggest a complex interaction between methylphenidate, age, and learning.