Supersensitivity of caudate neurones after repeated administration of haloperidol

The microiontophoretic potencies of dopamine, apomorphine and alpha-aminobutyric acid were examined on caudate neurones, using the same electrodes, in control animals and animals that had received 2mg/kg/day of haloperidol for 9 days. In the haloperidol group, a greater percentage of cells were inhibited by dopamine and apomorphine, indicating the development of a post-synaptic supersensitivity.