Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptaibols: models for ion channels.

J K Chugh1, B A Wallace

  • 1Department of Crystallography, Birkbeck College, University of London, London WC1E 7HX, UK.

Biochemical Society Transactions
|August 11, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cryo-EM structure of the human Kir7.1 channel reveals the molecular basis of snowflake vitreoretinal degeneration disease.

Communications biology·2026
Same author

Volatile anaesthetics modulate voltage-gated sodium channel function at a site directly linked to channel gating.

Nature communications·2026
Same author

Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating.

bioRxiv : the preprint server for biology·2024
Same author

Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole.

Nature communications·2024
Same author

DichroPipeline: A suite of online and downloadable tools and resources for protein circular dichroism spectroscopic data analyses, interpretations, and their interoperability with other bioinformatics tools and resources.

Protein science : a publication of the Protein Society·2023
Same author

DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy.

Communications biology·2023
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Peptaibols, fungal peptides with unique amino acids, form ion channels in membranes. Their structures are being modeled to understand antibiotic and channel-forming properties.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Biophysics

Background:

  • Peptaibols are fungal-derived, membrane-active polypeptides.
  • They contain unusual amino acids like alpha-aminoisobutyric acid and a C-terminal hydroxylated amino acid.
  • Peptaibols possess antibiotic properties against bacteria and fungi.

Purpose of the Study:

  • To analyze peptaibol sequences for common features related to channel formation.
  • To utilize crystal structures for modeling peptaibol channel assemblies.
  • To classify peptaibols into subfamilies based on sequence and structural data.

Main Methods:

  • Sequence alignment of over 200 reported peptaibol sequences.
  • Compilation of sequences in the Peptaibol Database.

Related Experiment Videos

  • Determination of crystal structures for selected peptaibols from different subfamilies.

    • Main Results:

    • Identification of related subfamilies (SFs) within the peptaibol dataset.
    • Establishment of common sequence features crucial for ion channel formation.
    • Generation of structural data for modeling peptaibol channels.

    Conclusions:

    • Peptaibol sequence and structure analysis aids in understanding their ion channel assembly.
    • Crystal structures provide a basis for modeling both known and novel peptaibol structures.
    • This research facilitates the study of peptaibol function and potential applications.