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Published on: January 13, 2016
Antigen presentation to CD8+ T cells: cross-priming in infectious diseases
1Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195-7370, USA. jdenhaan@u.washington.edu
Abstract:
Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.
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