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Updated: Jul 30, 2026

A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
CD1-specific T cells in microbial immunity
1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building, Room 518, Boston, MA 02115, USA. jgumperz@rics.bwh.harvard.edu
Abstract:
Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.
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