A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume
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Updated: Oct 5, 2026
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Y Yamanaka1, T Mammoto, T Kita
1Department of Anesthesiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, Japan.
Study Objective:
To investigate whether oral omeprazole 20 mg decreases the risk of aspiration pneumonia in patients with gastric tube reconstruction.
Design:
Consecutive study.
Setting:
Operation room of cancer center.
Patients:
Thirteen patients with gastric tube reconstruction for esophageal cancer.
Interventions:
Oral omeprazole 20 mg was given the night before surgery. A rapid-sequence induction with cricoid pressure was employed for induction of anesthesia. After tracheal intubation, a nasogastric catheter was inserted into the gastric tube and the contents were aspirated.
Measurements And Main Results:
The pH and volume of the gastric contents were measured. The pH and volume of the gastric tube contents were 4.5 +/- 1.6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), respectively. Food residue was recognized in nine patients. There was no patient with a pH below 2.5 and a volume of 25 mL or greater.
Conclusions:
Omeprazole 20 mg decreased the acidity and volume of the gastric tube contents and reduced the risk of aspiration pneumonia in patients with a gastric tube in place.
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