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Anti-angiogenesis therapy:concepts and importance of dosing schedules in clinical trials

Klaus Mross1

  • 1Tumor Biology Center at the Albert-Ludwigs University Freiburg

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|August 11, 2001
PubMed

Insights

Controlling new blood vessel growth (angiogenesis) is key to cancer treatment. Researchers are exploring various compounds and metronomic dosing to inhibit tumor angiogenesis, offering new therapeutic strategies.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and progression.
  • Understanding the intricate mechanisms regulating angiogenesis is vital for developing effective cancer therapies.

Purpose of the Study:

  • To review the biological control of angiogenesis in cancer.
  • To outline novel therapeutic strategies targeting tumor angiogenesis.

Main Methods:

  • Screening of various compounds, including protease inhibitors, endothelial cell proliferation inhibitors, angiogenic growth factor suppressors, and copper chelators, for their ability to inhibit tumor angiogenesis.
  • Discussion of the emerging concept of metronomic dosing regimens using conventional cytostatic agents as anti-angiogenic therapies.

Main Results:

  • Several classes of compounds have demonstrated inhibitory effects on tumor angiogenesis and are currently undergoing clinical trials.
  • Metronomic dosing represents a novel approach utilizing existing chemotherapy drugs for anti-angiogenic purposes.

Conclusions:

  • Inhibition of tumor angiogenesis presents a promising new modality for cancer treatment.
  • Further research and clinical evaluation are warranted to optimize anti-angiogenic strategies.

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