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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

M D Litt1, M Simpson, M Gaszner

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540, USA.

Science (New York, N.Y.)
|August 11, 2001
PubMed
Summary

Histone methylation patterns, specifically lysine 9 and lysine 4, are linked to gene activity during red blood cell development. Lysine 9 methylation correlates with gene silencing, while lysine 4 methylation is associated with active genes.

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