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[Synthesis and antibacterial activity of tricycic fluoroquinolones]
1Medicinal and Chemical Institute of China Pharmaceutical University, Nanjing 210009.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|May 1, 1997
Abstract:
Twelve new analogues of new tricyclic rufloxacin were prepared and their MIC were evaluated against thirteen kinds of bacteria. As a result of these studies: the polarity of C10-side chain was found to exert greater positive effect on G- than on G+ bacteria.