[The sesquiterpenoids from Celastrus flagellaris]

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Phytochemistry

Background:

• Celastrus flagellaris Rupr. is a plant species known for its potential medicinal properties.
• Seed oils of plants are often rich sources of diverse chemical compounds.
• Previous research may have identified some compounds from this plant, but a comprehensive analysis of its seed oil is warranted.

Purpose of the Study:

• To isolate and identify chemical constituents from the seed oil of Celastrus flagellaris Rupr.
• To characterize a novel sesquiterpenoid and other known compounds.
• To contribute to the understanding of the phytochemical diversity of Celastrus flagellaris.

Main Methods:

• Extraction of compounds from Celastrus flagellaris seed oil.
• Isolation of individual compounds using chromatographic techniques.
• Structure elucidation of isolated compounds using various spectroscopic methods including UV, IR, MS, and NMR (1H, 13C, DEPT, 1H-1H COSY, 13C-1H COSY, NOESY, HMBC).

Main Results:

• A new sesquiterpenoid, named celastrine B, was isolated.
• Seven known compounds were identified: 1 alpha, 6 beta, 13-triacetoxy-9 beta-benzoyloxy-beta-dihydroagarofuran, triptogelin G-1, 1 alpha, 6 beta-diacetoxy-9 beta-benzoyloxy-beta-dihydroagarofuran, triptogelin F-2, 1 alpha, 2 alpha-diacetoxy-9 beta-cinnamoyloxy-beta-dihydroagarofuran, celaforlin B-3, and 1 alpha, 6 beta-diacetoxy-8 alpha-cinnamoyloxy-9 alpha-benzoyloxy-beta-dihydroagarofuran.
• These compounds were isolated from the seed oil of Celastrus flagellaris for the first time.

Conclusions:

• The phytochemical investigation of Celastrus flagellaris seed oil led to the discovery of a new sesquiterpenoid and several known compounds.
• The structures of all isolated compounds were successfully determined through comprehensive spectroscopic analysis.
• This study expands the knowledge of the chemical constituents present in Celastrus flagellaris.