Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurochemical changes associated with schedule-controlled behavior.

S B Sparber

    Federation Proceedings
    |August 1, 1975
    PubMed
    Summary

    This study introduces a novel method combining radioisotope chemistry and brain perfusion to observe real-time changes in monoamines and behavior. This powerful tool aids in understanding drug-neurochemical-behavioral interactions and CNS plasticity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Food deprivation enhances both autoshaping and autoshaping impairment by a latent inhibition procedure.

    Behavioural processes·2014
    Same author

    Delaying reinforcement in an autoshaping task generates adjunctive and superstitious behaviors.

    Behavioural processes·2014
    Same author

    Embryonic "binge" cocaine exposure alters neural-immune and neural-endocrine interactions in young chickens: involvement of serotonin(2) receptors.

    Brain research. Developmental brain research·2001
    Same author

    Cocaine and salicylate: documentation of hydroxyl radical formation in hearts and brains of 18-day-old chick embryos and unexpected interactive toxicity.

    Psychopharmacology·2001
    Same author

    Embryonic cocaine exposure and corticosterone: serotonin(2) receptor mediation.

    Pharmacology, biochemistry, and behavior·2001
    Same author

    Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis.

    Free radical biology & medicine·2001

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Cerebrospinal fluid monoamine metabolites offer insights into central nervous system (CNS) metabolic changes.
    • Previous studies suggest a link between monoamine levels and complex behaviors.

    Purpose of the Study:

    • To develop and validate a technique for examining real-time changes in monoamine disposition in the brain.
    • To investigate the relationship between neurochemical dynamics and operant behavior.

    Main Methods:

    • Utilized radioisotope chemistry, operant behavior control, and push-pull brain perfusion.
    • Measured minute-to-minute changes in radiolabeled monoamine transmitter candidates and metabolites.
    • Observed changes in radiolabeled urea distribution as an extracellular marker.

    Main Results:

    • Monoamine levels dynamically co-varied with complex behaviors and psychotropic drug administration.
    • Observed transient changes in radiolabeled urea distribution alongside monoamine shifts.
    • Demonstrated that selective release or inhibition of monoamines can be modulated by specific drugs.
    • Showed that destruction of catecholamine nerve terminals attenuated signal-locked release of radiolabeled norepinephrine.

    Conclusions:

    • The developed technique provides a powerful tool for studying drug-neurochemical-behavioral interactions.
    • Supports the concept of dynamic changes in the CNS extracellular environment as a functional communication system.
    • Enables examination of plasticity, tolerance, and dependence in drug-neurochemical-behavioral interactions over extended periods.

    Related Experiment Videos