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Published on: February 25, 2016
[Effect of enkephalin on glial neurotrophic function related to the reduction of nitric oxide production]
1State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Shanghai Medical University, Shanghai 200032.
Abstract:
The effect of methionine-enkephalin (ME) on glial neurotrophic function was studied in rat cortical glial-neuronal coculture. The results showed that ME-treated glia enhanced neuronal survival by 28% (P < 0.05), and increased total neurite length per neuron by 11% (P < 0.05), while the expression of GAP-43 mRNA by 26% (P < 0.05). The effect of ME on NO production of glia was also studied in rat cortical glial culture. The result showed that different concentrations of ME (10(-12), 10(-10), 10(-8), 10(-6) mol/L) inhibited glial NO production. All the above show that the increase of glial neurotrophic ability by ME may be due to the inhibition of glial NO production.
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