Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmaceutically relevant metabolites from lichens.

K Müller1

  • 1Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität Münster, Germany. kmuller@uni-muenster.de

Applied Microbiology and Biotechnology
|August 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lichen metabolites. 1. Inhibitory action against leukotriene B4 biosynthesis by a non-redox mechanism.

Journal of natural products·1999
Same author

Reconstitution of the actin-scavenger system after orthotopic liver transplantation for end-stage liver disease: a prospective and longitudinal study.

Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·1999
Same author

Inhibition of keratinocyte growth by different Nepalese zanthoxylum species.

Phytotherapy research : PTR·1999
Same author

Early gene expression of NK cell-activating chemokines in mice resistant to Leishmania major.

Infection and immunity·1999
Same author

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.

Bone·1999
Same author

Overexpression of a C-terminal fragment of presenilin 1 delays anti-Fas induced apoptosis in Jurkat cells.

Neuroscience letters·1999

Lichen metabolites show diverse biological activities like antibiotic and anti-inflammatory effects, but their therapeutic potential is largely untapped. Further research into these natural compounds could yield new drug leads.

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Lichens produce a wide array of metabolites with diverse biological activities.
  • Known activities include antibiotic, anti-inflammatory, and cytotoxic effects.
  • Despite recognized potential, therapeutic applications of lichen metabolites remain largely unexplored.

Purpose of the Study:

  • To review common classes of lichen small-molecule constituents.
  • To discuss their chemical properties and potential therapeutic implications.
  • To highlight the need for further exploration in drug discovery.

Main Methods:

  • Literature review of lichen metabolites and their biological activities.
  • Focus on chemical classes: aliphatic acids, pulvinic acid derivatives, depsides, depsidones, dibenzofurans, anthraquinones, naphthoquinones, and epidithiopiperazinediones.

Related Experiment Videos

  • Analysis of therapeutic potential and challenges in medicinal chemistry.

    • Main Results:

    • Lichen metabolites exhibit a broad spectrum of pharmacological actions.
    • Key chemical classes and their associated biological effects are detailed.
    • The pharmaceutical potential is significant but underexploited.

    Conclusions:

    • Lichen metabolites represent a promising source for novel therapeutic agents.
    • Improved access and screening of these compounds are crucial for drug discovery.
    • Medicinal chemistry faces challenges and opportunities in developing lichen-derived drugs.