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Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice

F N Lauw1, S Florquin, P Speelman

  • 1Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.

Infection and Immunity
|August 14, 2001
PubMed

In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

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