Related Experiment Video
Updated: Aug 8, 2026

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
Published on: January 13, 2017
Pulsioxymetry monitorization during lower third molar extraction. A comparative study of three local anesthetics with
R Mestre Aspa1, I Carrera Grañó, L Berini Aytés
1Facultad de Odontología de la Universidad de Barcelona, España.
Abstract:
A double-blind, parallel non-randomized study is made to compare the heart rate and oxygen saturation levels in healthy patients subjected to lower third molar extractions under the effect of three different local anesthetics (4% articaine, 2% lidocaine, 2% mepivacaine) with the same epinephrine concentration (1:100,000). The patients were divided into three groups of 15 subjects each, according to the anesthetic employed. Heart rate and oxygen saturation were determined in each patient before and immediately after anesthetic injection, and again one minute after motor application to perform the ostectomy, at the start of force application to extract the tooth, on completing suture, and one week later at suture removal (the latter being taken as baseline reference). Blood pressure was also recorded, calculating the mean arterial pressure and the rate-pressure product (RPP) and pressure-rate quotient (PRQ). Only heart rate showed variations during the intervention, regardless of the local anesthetic used (based on a multifactor analysis of variance and considering statistical significance for p < 0.05). It may be concluded that none of the local anesthetics studied exert important effects upon the variables analyzed in healthy patients, though significant variations may arise due to the stress and/or anxiety associated to certain moments of lower third molar extraction.
More Related Videos
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
06:57Use of an Integrated Low-Flow Anesthetic Vaporizer, Ventilator, and Physiological Monitoring System for Rodents
Published on: July 9, 2020
Related Concept Videos
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Pharmacokinetics
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Parenteral Anesthetics: Overview