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[Morphological study of CD3+ dendritic epidermal T cells in human skin and scar]
1Plastic Surgery Institute, Chinese Academy of Medical Sciences, Beijing 100041.
Objective:
To investigate the CD3/TCR-bearing T cell in the epidermis and explore the influence of the dendritic epidermal T cells on regeneration and differentiation of epidermal cells.
Methods:
The CD3/TCR-bearing T cells in epidermis of human skin and cicatrix were examined by means of histomorphology and immunohistochemistry.
Results:
It was found that the density of CD3/TCR-bearing T cells in human skin and scar tissue had great dissimilarity. CD3+ dendritic epidermal T cells increased in hyperplastic scar. Such result was not observed in atrophic scar.
Conclusion:
Our findings indicate CD3+ dendritic epidermal T cells regulate the generation and differentiation of epidermal cells. CD3+ dendritic epidermal T cells may play an important role in the maintenance of the morphology of epidermal tissue.