Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

First experience with a ready-for-use rheohemapheresis system.

T Schreiner1, S Rink, R Brunner

  • 1Deutsches Hämapherese Zentrum, Cologne, Germany. med@dhzcologne.de

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|August 15, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global phylogenomic assessment of Leptoseris and Agaricia reveals substantial undescribed diversity at mesophotic depths.

BMC biology·2023
Same author

Multiplex planar bioassay with reduced diffusion on normal phase, identifying androgens, verified antiandrogens and synergists in botanicals via 12D hyphenation.

Food chemistry·2022
Same author

Multiplex planar bioassay detecting estrogens, antiestrogens, false-positives and synergists as sharp zones on normal phase.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2022
Same author

Twelve-month service use, suicidality and mental health problems of European adolescents after a school-based screening for current suicidality.

European child & adolescent psychiatry·2020
Same author

Miniature integrated micro-spectrometer array for snap shot multispectral sensing.

Optics express·2019
Same author

[Impact of early life maltreatment of women on the mother-child relationship : Data from mother-child dyads from Heidelberg and Berlin].

Der Nervenarzt·2019
Same journal

Therapeutic apheresis in transition: New indications and the emergence of precision apheresis.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same journal

Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same journal

Therapeutic plasma exchange in Alzheimer's disease: From clinical trial to real-world evidence.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same journal

Successful treatment of pure red cell aplasia with Orelabrutinib following major ABO-incompatible hematopoietic stem cell transplantation for acute myeloid leukemia: A case report.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same journal

Technological advances in selective plasma adsorption: The MTx.100 column and the emergence of subtractive precision medicine.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same journal

What's happening? Editorial comment: Insights on artificial intelligence, cell therapy and stem cell transplantation safety.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
See all related articles

A new rheohemapheresis system effectively improves microcirculation by filtering plasma, showing significant reductions in total protein, fibrinogen, and cholesterol with no major side effects observed in patients. Further protocol refinements are ongoing.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering

Background:

  • Rheohemapheresis is a therapeutic apheresis technique utilized to enhance microcirculatory function in various medical conditions.
  • Traditional methods involve plasma separation and secondary filtration, with recent advancements focusing on integrated systems.

Framework:

  • A novel CE-marked continuous flow blood separator (dideco Excel Pro) integrates a cell separator with a secondary hollow-fiber membrane filter.
  • The system features a connection kit and software enabling differential filtration as a standard protocol.

Implementation:

  • The new system was employed using ethylenevinylalcohol secondary filters (Evaflux LA4 or LA5) in 47 patients undergoing 99 procedures.
  • A median of 2.7 liters of plasma was processed per procedure, lasting a median of 109 minutes.

Related Experiment Videos

Implications:

  • Treatment resulted in significant reductions in peripheral blood levels of total protein, fibrinogen, and cholesterol.
  • A median 30% platelet loss was observed, with varying platelet concentrations in the separated plasma.
  • The system demonstrates readiness for clinical use, though protocol optimization is still necessary.