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Laboratory markers of hypercoagulability.

M L Rossi1, P A Merlini, D Ardissino

  • 1A. De Gasperis Cardiology Department, Hospital Niguarda Ca' Granda, Milan, Italy. marcolrossi@hotmail.com

Italian Heart Journal : Official Journal of the Italian Federation of Cardiology
|August 15, 2001
PubMed
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A prolonged hypercoagulable state, indicated by elevated hemostatic variables like fibrinogen, significantly increases the risk of myocardial infarction and sudden death, especially in younger individuals. New sensitive assays aid in defining these states.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Coronary artery thrombosis is the primary cause of myocardial infarction and unstable angina.
  • A prolonged hypercoagulable state is a recognized precursor to thrombotic events.
  • Established associations exist between plasma hemostatic variables and myocardial infarction frequency.

Purpose of the Study:

  • To analyze the significance of new, more sensitive assays for hypercoagulable states.
  • To define the role of these assays in various clinical conditions.
  • To understand the biochemical definition of hypercoagulability.

Main Methods:

  • Review of investigations over the last 40 years.
  • Analysis of associations between plasma hemostatic variables and myocardial infarction.

Related Experiment Videos

  • Evaluation of newly developed sensitive assays for hemostatic factors.

    • Main Results:

    • High levels of fibrinogen, factor VII/VIIa, tissue-type plasminogen activator, and plasminogen activator inhibitor are linked to increased risk of myocardial infarction, reinfarction, or sudden death.
    • This risk is comparable to that associated with high cholesterol, particularly in younger populations.
    • New sensitive assays enable precise biochemical definition of hypercoagulable states.

    Conclusions:

    • Elevated hemostatic variables represent a significant risk factor for thrombotic cardiovascular events.
    • Advanced diagnostic assays are crucial for accurately identifying and characterizing hypercoagulable states.
    • Understanding hypercoagulability is key to preventing myocardial infarction and related events.