Related Experiment Video

Updated: Jul 12, 2026

Demonstration of Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by Combining Current Measurements with Detection of Cleavage Fragments
08:56

Demonstration of Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by Combining Current Measurements with Detection of Cleavage Fragments

Published on: July 5, 2014

Ammonium interaction with the epithelial sodium channel.

N L Nakhoul1, K S Hering-Smith, S M Abdulnour-Nakhoul

  • 1Section of Nephrology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, Louisiana 70112, USA. nakhoul@tulane.edu

American Journal of Physiology. Renal Physiology
|August 15, 2001
PubMed
Summary

Ammonium chloride (NH4Cl) inhibits mouse epithelial sodium channels (mENaC) in Xenopus oocytes. This finding suggests NH4Cl affects sodium transport, potentially through channel permeability or selectivity, independent of intracellular acidification.

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