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Related Experiment Videos

Health Assessment Questionnaire modifications: is standardisation needed?

M M Zandbelt1, P M Welsing, A M van Gestel

  • 1Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands. M.Zandbelt@reuma.azn.nl

Annals of the Rheumatic Diseases
|August 15, 2001
PubMed
Summary

The Dutch Health Assessment Questionnaire (HAQ) versions HAQ90 and HAQ99 show comparable disability index scores. Standardized calculation, including aid correction, is crucial for international uniformity in rheumatoid arthritis trials.

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Area of Science:

  • Rheumatology
  • Clinical Trials
  • Health Outcomes

Background:

  • Physical disability is a key endpoint in rheumatoid arthritis (RA) clinical trials.
  • The Stanford Health Assessment Questionnaire Disability Index (HAQ DI) is widely used but lacks international uniformity due to translation and calculation variations.
  • The Dutch HAQ was revised from HAQ90 to HAQ99 to address these inconsistencies.

Purpose of the Study:

  • To compare disability index (DI) scores between the HAQ90 and HAQ99.
  • To evaluate the impact of different DI score calculation methods.

Main Methods:

  • 78 patients completed both HAQ99 and HAQ90 questionnaires.
  • Post hoc analysis of prospectively collected clinical trial data compared calculation methods.

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Main Results:

  • No significant difference in DI scores between HAQ90 and HAQ99 without aid/device correction.
  • Correction for aid/devices significantly altered DI scores.
  • Using mean vs. maximum item scores for category calculations resulted in non-comparable DI scores.

Conclusions:

  • International comparability of HAQ DI is maintained unless calculation variations, like omitting aid/device correction, interfere.
  • Standardized use and calculation of the HAQ DI, including aid/device correction and using maximum item scores, are recommended for global uniformity.