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Thyroid function and autoimmunity during interferon beta-1b treatment: a multicenter prospective study.

L Durelli1, B Ferrero, A Oggero

  • 1Clinica Neurologica, Dipartimento di Neuroscienze, Universitá di Torino, Italy. luca.durelli@unito.it

The Journal of Clinical Endocrinology and Metabolism
|August 15, 2001
PubMed
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Interferon-beta treatment for multiple sclerosis did not increase thyroid dysfunction or autoimmunity. Liver function alterations were significantly increased during treatment.

Area of Science:

  • Endocrinology
  • Neurology
  • Immunology

Background:

  • Type I interferon therapies, including interferon-alpha and interferon-beta, have been associated with thyroid dysfunction and autoimmunity.
  • Interferon-beta is a common treatment for multiple sclerosis.

Purpose of the Study:

  • To prospectively evaluate the frequency of thyroid dysfunction and autoimmunity in multiple sclerosis patients undergoing interferon-beta treatment.
  • To assess the correlation between thyroid alterations and antithyroid autoantibodies during treatment.

Main Methods:

  • 156 multiple sclerosis patients were followed for 1 year across 18 centers.
  • Serial clinical assessments and laboratory tests for thyroid and liver function, and antithyroid autoantibodies were performed every 3 months.
  • Statistical analysis using generalized estimating equations was employed to analyze longitudinal data.

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Main Results:

  • The de novo frequency of thyroid alteration was 8.3%, liver alteration was 37.5%, and antithyroid autoantibody positivity was 4.5% during interferon-beta treatment.
  • Liver alterations significantly increased during treatment (OR, 7.03; CI, 2.49-19.9).
  • No significant increase in thyroid alterations or antithyroid autoantibodies was observed, and thyroid dysfunction was not correlated with autoantibody positivity.

Conclusions:

  • Interferon-beta treatment for multiple sclerosis does not appear to increase the risk of thyroid dysfunction or autoimmunity.
  • Liver function alterations are a significant concern during interferon-beta therapy.
  • Monitoring liver function is crucial for patients treated with interferon-beta.