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Lamotrigine reduces painful diabetic neuropathy: a randomized, controlled study
E Eisenberg1, Y Lurie, C Braker
1Pain Relief Unit, Rambam Medical Center, The Technion-Israel Institute of Technology, Haifa, Israel. L_eisenberg@rambam.health.gov.il
Neurology
|August 15, 2001
Summary
Lamotrigine effectively reduced pain in patients with diabetic neuropathy. This study found lamotrigine to be a safe and beneficial treatment option for neuropathic pain.
Area of Science:
- Neurology
- Pharmacology
- Pain Management
Background:
- Diabetic neuropathy is a common complication of diabetes.
- Neuropathic pain significantly impacts patient quality of life.
Purpose of the Study:
- To evaluate the efficacy and safety of lamotrigine for diabetic neuropathy pain.
Main Methods:
- A 6-week randomized controlled trial involving 59 patients.
- Patients received titrated lamotrigine (25-400 mg/day) or placebo.
- Pain intensity was measured using a numerical pain scale (NPS).
Main Results:
- Lamotrigine significantly reduced daily NPS scores compared to placebo (p < 0.001).
- Global assessment favored lamotrigine, with similar adverse event profiles.
- No significant changes were observed in secondary measures like MPQ, BDI, or PDI.
Conclusions:
- Lamotrigine demonstrates efficacy in alleviating pain associated with diabetic neuropathy.
- The drug is well-tolerated and presents a safe treatment option.